Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prevention of acute graft-vs.-host disease: Effect on chronic graft-vs.-host disease and long-term survival
نویسندگان
چکیده
منابع مشابه
Alternating-day cyclosporine and prednisone for treatment of high-risk chronic graft-v-host disease.
Therapy of chronic graft-v-host disease (GVHD) has been unsatisfactory in patients with platelet counts less than 100,000/microL. Survival at 5 years after marrow transplant is only 26% in such patients treated with trimethoprim-sulfamethoxazole (TMP-SMX) and every other day with prednisone. Since October 1982, 61 patients with high-risk extensive chronic GVHD were treated with a new alternatin...
متن کاملTherapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone.
Results of previous studies have suggested that transplantation-related mortality among patients with chronic graft-versus-host disease (GVHD) may be reduced by combined treatment with cyclosporine (CSP) and prednisone rather than by prednisone alone. In a randomized trial, we assessed the efficacy of cyclosporine plus prednisone versus prednisone alone as initial therapy for chronic GHVD among...
متن کاملRisk factors for acute graft-versus-host disease associated with cyclosporine and methotrexate prophylaxis.
We were interested in the recent report by Nash et all of their analysis of risk factors for acute graft-versus-host disease (GVHD) in a large series of patients undergoing allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling. One of their conclusions was that patients who received reduced doses of cyclosporine A (CSP) or methotrexate (MTX) were at higher risk of developin...
متن کاملRisk Factors for Acute Graft-versus-host Disease Associated with Cyclosporine and Methotrexate Prophylaxis
We were interested in the recent report by Nash et all of their analysis of risk factors for acute graft-versus-host disease (GVHD) in a large series of patients undergoing allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling. One of their conclusions was that patients who received reduced doses of cyclosporine A (CSP) or methotrexate (MTX) were at higher risk of developin...
متن کاملRisk Factors for Acute Graft-versus-host Disease Associated with Cyclosporine and Methotrexate Prophylaxis
We were interested in the recent report by Nash et all of their analysis of risk factors for acute graft-versus-host disease (GVHD) in a large series of patients undergoing allogeneic bone marrow transplantation (BMT) from an HLA-identical sibling. One of their conclusions was that patients who received reduced doses of cyclosporine A (CSP) or methotrexate (MTX) were at higher risk of developin...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 1999
ISSN: 1083-8791
DOI: 10.1016/s1083-8791(99)70003-0